Tromantadine is an antiviral drug that is used to treat herpes simplex virus. It is in a topical gel under trade names Viru Viru-Merz Merz Serol available. Its performance is similar to aciclovir.The inclusion criteria required that patients who have a history of recurrent outbreaks of herpes orofacialis and they should not take within 24 hours after the first prodromal symptoms.The average time are recruited between the first signs of a new relapse and the start of treatment was 07 o'clock in the two treatment groups. The course of the healing process was evaluated by 4 subjective symptoms (itching, burning, tightness in the skin and pain), and the following objective criteria: number of days, vesicular stage and duration of complete healing, aborted lesions and new lesions. As rimantadine, amantadine, and adapromine tromantadine is a derivative of adamantane.
