Product name:Ampicillin Sodium
Product description:Ampicillin Sodium is similar to benzyl penicillin in its bactericidal action against sensitive organisms during the stage of active multiplication. It acts through the inhibition of biosynthesis of cell wall mucopeptide. Ampicillin Sodium differs in in vitro spectrum from benzyl penicillin in the Gram-negative spectrum. It exerts high in vitro activity against many strains of Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Neisseria catarrhalis, Escherichia coli, Proteus mirabilis, Bacteroides funduliformis, Salmonellae and Shigellae.
In vitro studies have also demonstrated the sensitivity of many strains of the following Gram-positive bacteria: alpha- and beta-hemolytic streptococci, Diplococcus pneumoniae , nonpenicillinase-producing staphylococci, Bacillus anthracis, and most strains of enterococci and clostridia. Ampicillin generally provides less in vitro activity than penicillin G against Gram-positive bacteria. Because it does not resist destruction by penicillinase, it is not effective against penicillinase-producing bacteria, particularly resistant staphylococci. All strains of Pseudomonas and most strains of Klebsiella and Aerobacter are resistant.
Pharmacokinetics:
Ampicillin Sodium diffuses readily into all body tissues and fluids with the exception of brain and spinal fluid except when meninges are inflamed. It produces high and persistent blood levels. Most of the Ampicillin is excreted unchanged in the urine and this excretion can be delayed by concurrent administration of probenecid. The active form appears in the bile in higher concentrations than found in the serum. Ampicillin Sodium is one of the least serum bound of all the penicillins, averaging about 20% compared to approximately 60%-90% for other penicillins.INDICATIONS AND USAGE
Ampicillin Sodium is indicated in the treatment of infections due to susceptible strains of the following:
1.Gram-negative Organisms
Shigellae, Salmonellae (including S. typhosa), H. influenzae, E. coli, P. mirabilis, N. gonorrhoeae, and N. meningitidis.
2.Gram-positive Organisms
Streptococci, D. pneumoniae, and nonpenicillinase-producing staphylococci.
Because of its wide spectrum and bactericidal action, it may be useful in instituting therapy; however, bacteriological studies to determine the causative organisms and their sensitivity to Ampicillin should be performed.
Indicated surgical procedures should be performed.
CAS No.:69-52-3
Synonyms: Ampcilliin Natricum;
Molecular Formula: C16H18N3NAO4S