Aldolase is a lyase, the narrow sense refers to the catalytic cracking of a 1.6-diphosphate-D-fructose to generate 3 - phosphate-D-glyceraldehyde and the response of alpha-dihydroxyacetone phosphate synthase (gluconeogenesis can catalyze the reverse reaction of the reaction), referring to the 1.6-diphosphate-D-fructose aldolase (Ec 4.1.2.13). (A broad sense refers to the catalytic reaction with the form of the enzyme, for example, also rhamnose phosphate aldehyde reduction enzymes collectively referred to as aldolase).
This reaction is reversible aldol condensation. △ G ° '= 5.73 kcal. Department of an almost exists in all creatures glycolysis enzymes. From yeast, purified skeletal muscle. Standard samples from the yeast α, α 'one pair of pyridine or cysteine inactivation of Fe2 + and Zn2 +, of Co2 +, Cu2 +-activated metal protein, muscle or plant tissue enzyme is not dual pyridine inhibited in skeletal muscle, this enzyme's molecular weight of about 150,000, consists of four major subunits. Addition aldolase In addition to the above reaction, also the role of a variety of aldehydes with dihydroxyacetone phosphate condensation. For example:
Dihydroxyacetone phosphate + D-glyceraldehyde - phosphate-D-fructose phosphate dihydroxyacetone + L-glyceraldehyde - dihydroxyacetone phosphate-L-sorbose phosphate acetone + acetaldehyde 5 - deoxy - 1 - phosphate-L-xylulose.
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