Posted in Pharmaceutical materials, Pharmaceutical Raw Materials 06. Jan, 2012 · Edit
Drug Name: ATABRINE HYDROCHLORIDE Common Name: A flat formerly known as hydrochloric acid: hydrochloric acid Mi Palin, malaria polyester flat English name: Atebrinum Hydrochloridum dosage form: Injection Product No.: 1004598CAS Registry Number: 69-05-6
Composition
Molecular formula: C23H30ON3Cl · 2HCl · 2H2O Molecular weight: 472.88 Properties of bright yellow crystalline powder; odorless, bitter taste. Soluble in water (1:40), and ethanol.
IndicationsWith this product antimalarial chloroquine phosphate is similar, but weaker and shorter than the latter. Major role in the erythrocytic stage, to control the symptoms of malaria, treatment of malaria, can be used for prevention. In addition to the pear-shaped giardiasis and taeniasis have a certain effect, has in recent years for cancer of the pleural effusion.
Dosage Malaria: treatment with the first day each 0.2g, 3 times a day; the second day of each 0.1g, 3 times a day, once every 6 days. Preventive, each 0.1g, daily or every other day, even for 6 days. Treatment with children, 1 to 4 years old, the first day, each 0.05g, 3 times a day, each subsequent 0.05g, 2 times a day; 5 to 8 years old, the first day, each 0.1g, each 3 times a day, after 2 times a day; 9 to 12 years old, the first day, each 0.2g, 3 times a day, after 2 times a day, were even served 6. Taeniasis: Each 0.8g, fasting Dayton clothing (or each 0.2g, each 10minl times, even four times, and each additional serving of sodium bicarbonate 0.3g); children daily 15mg/kg, 4h after the service magnesium sulfate 1. Pear giardiasis: Daily 0.3g, three times a day for 5d; children 2 years of age, daily 8mg/kg, three times, take 4 ~ 5d. Inhibition of cancer pleural effusion: general for the first time 0.05 ~ 0.2g, dissolved in 10ml of water slowly into the pleural cavity, 0.2 to 0.4 after day, once every 3 ~ 5d. Amount of discretion by malignant ascites.
Adverse reactions
Less toxic, the skin yellow, 1 to 2 months after discontinuation go away. Another loss of appetite, nausea, vomiting vomiting, abdominal pain, if administered after a meal or a meal or when equal amount of sodium bicarbonate with the service, reduce response.
Note Large doses can cause toxic hepatitis.
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