Posted in Pharmaceutical materials, Pharmaceutical Raw Materials 13. Jan, 2012 · Edit
Levamisole, the racemic Tetramisole with d-camphor -10– acid cyclization, hydrolysis of salt derived. Or DL-Tetramisole The split, with caustic soda and, to be L-four imidazole, and finally salt derived. Levamisole (levamisole) is a broad-spectrum anthelmintics drugs, mainly used for expelling worms and hook worms. It can be used to improve the patient’s resistance to bacterial and viral infections. The current trial in lung cancer, breast cancer surgery or acute leukemia, lymphoma deterioration after chemotherapy as adjuvant therapy. In addition, they can still be used autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and the flu, children with respiratory infections, hepatitis, dysentery, boils, abscesses, etc. Of intractable bronchial asthma proved by the recent preliminary trials a significant effect. Levamisole is a broad-spectrum anthelmintics drugs, mainly used for expelling worms and hook worms. It can be used to improve the patient’s resistance to bacterial and viral infections. The current trial in lung cancer, breast cancer surgery or acute leukemia, lymphoma deterioration after chemotherapy as adjuvant therapy. In addition, they can still be used autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and the flu, children with respiratory infections, hepatitis, dysentery, boils, abscesses, etc. Of intractable bronchial asthma proved by the recent preliminary trials a significant effect.
Pharmacokinetic study
Analysis of solid thiazoles deworming drugs levamisole thermal decomposition process using thermal gravimetric analysis and differential scanning calorimetry method to study the drug levamisole kinetics of thermal decomposition, thermal decomposition kinetic parameters calculated E, A , γ; combined with quantum chemical calculations of the organic structure of the bond length, atomic electrostatic charge of the thermal decomposition mechanism, and infer the mechanism of thermal decomposition products and the storage period. using thermal analysis of solid drug levamisole simple thermal decomposition method reliable results.
Pharmacological studies
Levamisole in the prevention of cercariae of Schistosoma japonicum infection. Methods and levamisole hydrochloride oral dose of levamisole base 26.25 mg / kg, respectively, in the first 2 days of oral infection in mice, even 7 d; coated skin dose 1.0%, 2.0%, 3.0%, 5.0% and 7.0%, respectively, in 2,1 days before the day of infection painted skin. dissected 4 weeks after stopping the seizure of parasites results levamisole hydrochloride solution and levamisole alkaline aqueous solution, respectively, oral, between the worm reduction rate of 0; 5.0% levamisole hydrochloride in the day of infection painted skin, 7.0% levamisole hydrochloride in coated skin 1 day before infection, worm reduction rates were 100.0%; 2.0%, 3.0% and 5.0% of levamisole base applicator in 1 day before infection, worm reduction rate can reach 100.0% Conclusion levamisole lotion to cercariae of Schistosoma japonicum infection defense, excellent results levamisole base in levamisole hydrochloride Oral invalid.
Observation of levamisole (LMS) on experimental allergic encephalomyelitis (EAE) rat spinal cord mononuclear cells, CD4, CD28 and CD152 expression, and to explore the LMS-induced inflammatory demyelinating leukoencephalopathy Pathogenesis. Method using flow cytometry EAE rat spinal cord mononuclear cells, CD4, CD28 and CD152 expression. LMS results and pre-treatment group while the spinal cord of EAE rats mononuclear cells and CD28 on CD4 expression levels were significantly higher than non-treated EAE model LMS group. Conclusion LMS can promote EAE rat spinal cord mononuclear cells, CD4 and CD28 expression, suggesting that LMS increases the expression of CD4 and CD28 may LMS-induced inflammatory demyelinating leukoencephalopathy related.
The study of levamisole on cell-mediated immunity and humoral chicken immune function. The results show that levamisole can affect immune function in normal chickens: Levamisole can significantly promote the proliferation of chicken T lymphocytes, but no significant effect on B lymphocytes: 2.5 ¯ 10mg/kg levamisole can CD4 ^ + / CD8 ^ + lymphocytes were significantly increased; levamisole can chicken in vivo anti-particulate, thymus-dependent antigen SRBC antibody titers, anti-soluble, thymus-dependent antigen-BSA antibody titers and the Anti-SARS thymus-dependent antigen BA antibody titers were significantly increased;
Adverse reactions and attention: occasional dizziness, nausea, vomiting, abdominal pain, loss of appetite, fever, lethargy, fatigue, skin rashes, itching and other adverse reactions, after stopping to relieve itself. Individual patients may have leukopenia, exfoliative dermatitis and liver injury .
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