Product name : Ketoconazole
Synonyms : nizoral;R-41400;
CAS No. : 65277-42-1
Molecular Formula : C26H28Cl2N4O4
Mol. Mass : 531.431 g/mol
Product descrption :
Ketoconazole is a synthetic antifungal drug used to prevent and treat fungal skin infections, especially in immunocompromised patients such as those with AIDS or those on chemotherapy. Ketoconazole is sold commercially as an anti-dandruff shampoo, topical cream, and oral tablet, under the trademark name Nizoral , Australia and Canada, as Sebizole by Douglas Pharmaceuticals in Australia and New Zealand and as Ketomed in Latin America.In Spain, products with ketoconazole as main agent include Ketoisdin gel 2% (gel) and Fungarest (topical 30 g cream).
Ketoconazole is very lipophilic, which leads to accumulation in fatty tissues. The less toxic and more effective triazole compounds fluconazole and itraconazole have largely replaced ketoconazole for internal use.[citation needed] Ketoconazole is best absorbed at highly acidic levels, so antacids or other causes of decreased stomach acid levels will lower the drug's absorption when taken orally. Absorption can be increased by taking it with an acidic beverage, such as cola.