Nifurpirinol, 6-hydroxymethyl-2-[2-(5-nitro-2-furyl)vinyl]pyridine, which has been broadly acclimated as an antibacterial biologic adjoin diseases of fish, was begin to be a almighty mutagen. The mutagenic aftereffect was dose-related, and the potencies were affected to be 1.49 X 10, 7.24 X 10 and 8.49 X 10revertants/1 X 10 survivors at the absorption of 1 microgram/ml to :Escherichia coli B/r WP2, E. coli B/r WP2 hcr- and Salmonella typhimurium TA100, respectively, after metabolic activation.
Nifurpirinol is affected to photodegradation, and its mutagenic action to S. typhimurium TA100 was decreased to about one thousandth if the band-aid of Nifurpirinol was apparent to sunlight at allowance temperature for 4 h.