Chloramphenicol is white acicular or microstrip yellow-green needles, longflake crystalls or crystal powder; Bitter taste. In methanol, ethanol, acetone, propylene glycol easily dissolved. Stable when dry, relatively stable in weak acid and neutral solution, boil no decomposition, in the base class is easy to fail.
Chloramphenicol is produced by venezuela chain thermosphacta antibiotics, antibacterial sex broad-spectrum antibiotics. Is the first choice for treatment of typhoid and paratyphoid medicine, treatment of anaerobic bacteria infection is one of the powerful drug, the second for the treatment of various infectious diseases caused by sensitive microbes. Because of the hematopoietic system has serious adverse reactions, need to be used carefully.
Chloramphenicol as broad-spectrum antibacterial agent. Through fat-soluble can diffuse into the bacterial cells, mainly in the 70 s of bacteria the 50 s ribosomal subunit, inhibit transpeptidase, make the growth of the peptide chain, inhibiting the formation of peptide chain, so as to prevent the synthesis of protein. High concentration or this article highly sensitive bacteria has antiseptic effect.
